Pain Pill Addiction and its receptors

Pain Pill Addiction acts on two classes of receptors D1-like "and" D2-like "which are both metabolism but have nearly opposite effects: the D1-like (D1 and D5) are coupled via Gs to adenylyl cyclase and allow the production of cAMP which triggers many metabolic responses dependent protein kinase A. The D2-like (D2, D3, D4) are coupled to Gi / o and inhibit the synthesis of cAMP which in particular facilitates the opening of K + channels hyper-polarisator.

Pain Pill Addiction neurons are mainly gathered in two mesencephalic nuclei. One is the tegmentum or ventral tegmental area (ATV or area mesencephalic A10) whose axonal projections innervate the cortex (especially the older), the limbic system (especially the septum and amygdala) and cores of the base (putamen and nucleus accumbens). Most of these fibers pass through the beam median telencephalon (FMT) and are involved in processing information on cognitive and emotional. In fact, the neural wiring is the system of reward / reinforcement which produced strong stimulation brain to feel pleasure (hedonic action) when behavior essential to the survival of the individual or species. This circuit of motivation that was hijacked by drugs. Thus they, producing pleasure motivates the person to a compulsive behavior that drug replaces survival behaviors.

The other is Pain Pill Addiction emitting axons to the striatum (caudate nucleus and putamen) and participates in the control of locomotion. Drugs that alter the level of release of Pain Pill Addiction in the striatum motoric upset. (One last beam Pain Pill Addiction innervates the hypothalamic-pituitary influence endocrine secretions and behavior controlled by the hypothalamus.)
It is the main structure controlling the programming and implementation of behavior engines. The origins of excitatory signals and cortical sensory motor thalamic converge and are integrated and redistributed to other basal ganglia also involved in the control of locomotion (substantia nigra, globus pallidus, nucleus sousthalamique). Within the basal ganglia, the regulation of the motor is due to a balance between stimuli (glutamate and Pain Pill Addiction) and inhibitions (GABA), on each other, the different cores. Moreover, this balance is adjusted to "the decline" by the endocannabinoid.